About the Authors

Manav Kapoor

Contributed equally to this work with: Manav Kapoor, Jen-Chyong Wang

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Jen-Chyong Wang

Contributed equally to this work with: Manav Kapoor, Jen-Chyong Wang

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Sarah Bertelsen

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Kathy Bucholz

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

John P. Budde

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Anthony Hinrichs

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Arpana Agrawal

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Andrew Brooks

Affiliation Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

David Chorlian

Affiliation Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, New York, United States of America

Danielle Dick

Affiliation Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, United States of America

Victor Hesselbrock

Affiliation Department of Psychiatry, University of Connecticut, Farmington, Connecticut, United States of America

Tatiana Foroud

Affiliation Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

John Kramer

Affiliation Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Samuel Kuperman

Affiliation Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Niklas Manz

Affiliation Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, New York, United States of America

John Nurnberger Jr

Affiliation Department of Psychiatry, College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Bernice Porjesz

Affiliation Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, New York, United States of America

John Rice

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Jay Tischfield

Affiliation Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

Xiaoling Xuei

Affiliation Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

Marc Schuckit

Affiliation Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America

Howard J. Edenberg

Affiliation Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, Indiana, United States of America

Laura J. Bierut

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Alison M. Goate

goatea@psychiatry.wustl.edu

Affiliation Department of Psychiatry, School of Medicine, Washington University, St. Louis, Missouri, United States of America

Competing Interests

Dr. Bierut, Dr. Goate and Dr. Wang are listed as inventors on the patent “Markers for Addiction” (US 20070258898) covering the use of certain SNPs in determining the diagnosis, prognosis, and treatment of addiction. Dr. Bierut acted as a consultant for Pfizer, Inc. in 2008. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: J-CW AG KB VH JK SK JN BP MS HJE LJB. Performed the experiments: J-CW JB. Analyzed the data: MK SB TH. Phenotype Data Collection: KB VH JK SK JN BP MS HJE LJB Wrote first draft of paper: MK J-CW AG Reviewed and contributed in writing the paper: MK J-CW AG KB AA AB DC DD VH TF JK SK NM JN BP JR JT XX MS HJE LJB.