About the Authors

Masakazu Nakano

Contributed equally to this work with: Masakazu Nakano, Yoko Ikeda, Yuichi Tokuda

Affiliation Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan

Yoko Ikeda

Contributed equally to this work with: Masakazu Nakano, Yoko Ikeda, Yuichi Tokuda

Affiliation Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Yuichi Tokuda

Contributed equally to this work with: Masakazu Nakano, Yoko Ikeda, Yuichi Tokuda

Affiliation Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan

Masahiro Fuwa

Affiliations Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan, Research and Development Center, Santen Pharmaceutical Co. Ltd., Nara, Japan

Natsue Omi

Affiliation Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan

Morio Ueno

Affiliation Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Kojiro Imai

Affiliation Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Hiroko Adachi

Affiliation Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan

Masaaki Kageyama

Affiliation Research and Development Center, Santen Pharmaceutical Co. Ltd., Nara, Japan

Kazuhiko Mori

Affiliation Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Shigeru Kinoshita

tashiro@koto.kpu-m.ac.jp (KT); shigeruk@koto.kpu-m.ac.jp (SK)

Affiliation Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Kei Tashiro

tashiro@koto.kpu-m.ac.jp (KT); shigeruk@koto.kpu-m.ac.jp (SK)

Affiliation Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan

Competing Interests

This study has been completed under the Collaborative Research Agreement executed by Kyoto Prefectural University of Medicine and Santen Pharmaceutical Co., Ltd. All materials and information produced throughout this study are parts of co-owned intellectual properties. MF and MK are employees of Santen Pharmaceutical Co., Ltd. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SK KT. Performed the experiments: MN YI NO MU KI HA KM. Analyzed the data: MN YT SK KT. Contributed reagents/materials/analysis tools: YI MF MU KI MK KM SK. Wrote the paper: MN YI YT KM SK KT.