About the Authors

Piero Ruggenenti

Contributed equally to this work with: Piero Ruggenenti, Flavio Gaspari

Affiliations Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy, Unit of Nephrology, Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy

Flavio Gaspari

Contributed equally to this work with: Piero Ruggenenti, Flavio Gaspari

Affiliation Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy

Antonio Cannata

Affiliation Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy

Fabiola Carrara

Affiliation Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy

Claudia Cella

Affiliation Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy

Silvia Ferrari

Affiliation Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy

Nadia Stucchi

Affiliation Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy

Silvia Prandini

Affiliation Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy

Bogdan Ene-Iordache

Affiliation Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy

Olimpia Diadei

Affiliation Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy

Norberto Perico

Affiliation Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy

Patrizia Ondei

Affiliation Unit of Nephrology, Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy

Antonio Pisani

Affiliation Azienda Ospedaliera Universitaria Federico II, Napoli, Italy

Erasmo Buongiorno

Affiliation Presidio Ospedaliero V. Fazzi, Lecce, Italy

Piergiorgio Messa

Affiliation Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy

Mauro Dugo

Affiliation Azienda ULSS 9 – Ospedale S. Maria di Ca' Foncello, Treviso, Italy

Giuseppe Remuzzi

giuseppe.remuzzi@marionegri.it

Affiliations Clinical Research Center for Rare Diseases Aldo & Cele Daccò, Mario Negri Institute for Pharmacological Research, Bergamo, Italy, Unit of Nephrology, Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy

for the GFR-ADPKD Study Group

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PR FG GR NP. Performed the experiments: FG AC FC CC SF NS. Analyzed the data: CC FC BEI. Contributed reagents/materials/analysis tools: FG AC FC CC SF NS. Wrote the paper: PR FG GR NP. Contributed to data analyses and interpretation: PR FG GR NP. Wrote the initial draft of the manuscript: PR FG GR NP. Coordinated the activities of the Laboratory of the Clinical Research Center where all the GFR measurements were centralized: FG. Performed all the laboratory analyses: AC FC CC SF NS. Contributed to the statistical analyses: CC FC. Coordinated the activities of the Day Hospital of the Clinical Research Center where the clearance studies were performed: SP. Monitored all the activities of the clinical trials: OD. Generated the data bases and contributed to data handling: BE-I. Contributed to patient identification, monitoring and care: NP PO AP EB PM MD.