Investigating the Structural Impacts of I64T and P311S Mutations in APE1-DNA Complex: A Molecular Dynamics Approach

C. George Priya Doss; N. NagaSundaram

doi:10.1371/journal.pone.0031677

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Open Access

Peer-reviewed

Research Article

Investigating the Structural Impacts of I64T and P311S Mutations in APE1-DNA Complex: A Molecular Dynamics Approach

C. George Priya Doss ,

* E-mail: georgepriyadoss@vit.ac.in

Affiliation Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India
⨯
N. NagaSundaram

Investigating the Structural Impacts of I64T and P311S Mutations in APE1-DNA Complex: A Molecular Dynamics Approach

C. George Priya Doss,
N. NagaSundaram

Published: February 27, 2012
https://doi.org/10.1371/journal.pone.0031677

About the Authors

C. George Priya Doss

* E-mail: georgepriyadoss@vit.ac.in

Affiliation Centre for Nanobiotechnology, Medical Biotechnology Division, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India

N. NagaSundaram

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CGPD NN. Performed the experiments: CGPD NN. Analyzed the data: CGPD NN. Contributed reagents/materials/analysis tools: CGPD NN. Wrote the paper: CGPD NN.

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Hydrogen bonding
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Salt bridges
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Protein structure
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Biochemical simulations
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Molecular dynamics
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Protein structure prediction
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DNA-binding proteins
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Single nucleotide polymorphisms
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