About the Authors

Carlos Cruchaga

cruchagc@psychiatry.wustl.edu (CC); goatea@psychiatry.wustl.edu (AMG)

Affiliation Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University, St. Louis, Missouri, United States of America

Sumitra Chakraverty

Affiliation Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University, St. Louis, Missouri, United States of America

Kevin Mayo

Affiliation Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University, St. Louis, Missouri, United States of America

Francesco L. M. Vallania

Affiliation Department of Genetics, Washington University, St. Louis, Missouri, United States of America

Robi D. Mitra

Affiliation Department of Genetics, Washington University, St. Louis, Missouri, United States of America

Kelley Faber

Affiliation Department of Medical and Molecular Genetics, Indiana University, Indianapolis, United States of America

Jennifer Williamson

Affiliation Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

Tom Bird

Affiliation VA Medical Center and Departments of Neurology and Medicine, University of Washington, Seattle, Washington, United States of America

Ramon Diaz-Arrastia

Affiliation Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Tatiana M. Foroud

Affiliation Department of Medical and Molecular Genetics, Indiana University, Indianapolis, United States of America

Bradley F. Boeve

Affiliation Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

Neill R. Graff-Radford

Affiliation Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States of America

Pamela St. Jean

Affiliation Genetics, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

Michael Lawson

Affiliation Genetics, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

Margaret G. Ehm

Affiliation Genetics, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America

Richard Mayeux

Affiliation Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, New York, United States of America

Alison M. Goate

cruchagc@psychiatry.wustl.edu (CC); goatea@psychiatry.wustl.edu (AMG)

Affiliations Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University, St. Louis, Missouri, United States of America, Department of Genetics, Washington University, St. Louis, Missouri, United States of America

for the NIA-LOAD/NCRAD Family Study Consortium

Competing Interests

The authors have read the journal's policy and have the following conflicts: PSJ, ML and ME are employed by GlaxoSmithKline. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CC R. Mayeux AG. Performed the experiments: CC SC KM. Analyzed the data: CC SC KM FV Robi Mitra. Contributed reagents/materials/analysis tools: KF JW TB RD TF BB NG PST ML ME R. Mayeux. Wrote the paper: CC AG.