Deducing the Temporal Order of Cofactor Function in Ligand-Regulated Gene Transcription: Theory and Experimental Verification

Edward J. Dougherty; Chunhua Guo; S. Stoney Simons Jr; Carson C. Chow

doi:10.1371/journal.pone.0030225

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Open Access

Peer-reviewed

Research Article

Deducing the Temporal Order of Cofactor Function in Ligand-Regulated Gene Transcription: Theory and Experimental Verification

Edward J. Dougherty,

Affiliation Steroid Hormones Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Chunhua Guo,

Affiliation Steroid Hormones Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
S. Stoney Simons Jr ,

* E-mail: steroids@helix.nih.gov (SSS); carsonc@niddk.nih.gov (CCC)

Affiliation Steroid Hormones Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Carson C. Chow

* E-mail: steroids@helix.nih.gov (SSS); carsonc@niddk.nih.gov (CCC)

Affiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Deducing the Temporal Order of Cofactor Function in Ligand-Regulated Gene Transcription: Theory and Experimental Verification

Edward J. Dougherty,
Chunhua Guo,
S. Stoney Simons Jr,
Carson C. Chow

Published: January 17, 2012
https://doi.org/10.1371/journal.pone.0030225

About the Authors

Edward J. Dougherty

Affiliation Steroid Hormones Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Chunhua Guo

S. Stoney Simons Jr

* E-mail: steroids@helix.nih.gov (SSS); carsonc@niddk.nih.gov (CCC)

Carson C. Chow

* E-mail: steroids@helix.nih.gov (SSS); carsonc@niddk.nih.gov (CCC)

Affiliation Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SSS CCC. Performed the experiments: EJD CG SSS. Analyzed the data: SSS CCC. Contributed reagents/materials/analysis tools: EJD CG SSS CCC. Wrote the paper: SSS CCC.

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Graphs
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Biochemical cofactors
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Transfection
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Protein expression
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Steroids
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Luciferase
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Competitive inhibitors
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Linear regression analysis
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