Cooperative Regulation of Non-Small Cell Lung Carcinoma by Nicotinic and Beta-Adrenergic Receptors: A Novel Target for Intervention

Hussein A. N. Al-Wadei; Mohammed H. Al-Wadei; Hildegard M. Schuller

doi:10.1371/journal.pone.0029915

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Open Access

Peer-reviewed

Research Article

Cooperative Regulation of Non-Small Cell Lung Carcinoma by Nicotinic and Beta-Adrenergic Receptors: A Novel Target for Intervention

Hussein A. N. Al-Wadei,

Affiliations Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America, Department of Preventive Medicine, Sana'a University, Sana'a, Yemen
⨯
Mohammed H. Al-Wadei,

Affiliation Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America
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Hildegard M. Schuller

* E-mail: hmsch@utk.edu

Affiliation Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America
⨯

Cooperative Regulation of Non-Small Cell Lung Carcinoma by Nicotinic and Beta-Adrenergic Receptors: A Novel Target for Intervention

Hussein A. N. Al-Wadei,
Mohammed H. Al-Wadei,
Hildegard M. Schuller

Published: January 12, 2012
https://doi.org/10.1371/journal.pone.0029915

About the Authors

Hussein A. N. Al-Wadei

Affiliations Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America, Department of Preventive Medicine, Sana'a University, Sana'a, Yemen

Mohammed H. Al-Wadei

Affiliation Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America

Hildegard M. Schuller

* E-mail: hmsch@utk.edu

Affiliation Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HMS. Performed the experiments: HANA MHA. Analyzed the data: HMS HANA MHA. Wrote the paper: HANA HMS. Obtained funding: HMS.

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Nicotine
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Non-small cell lung cancer
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Gamma-aminobutyric acid
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Nicotine replacement therapy
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Nicotinic acetylcholine receptors
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Neurotransmitters
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Epinephrine
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Adenylyl cyclase signaling cascade
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