About the Authors

Kazutaka Ohi

Affiliations Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan, National Hospital Organization, Yamato Mental-Medical Center, Nara, Japan, Core Research for Evolutionary Science and Technology of Japan Science and Technology Agency, Saitama, Japan

Ryota Hashimoto

hashimor@psy.med.osaka-u.ac.jp

Affiliations Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan, Core Research for Evolutionary Science and Technology of Japan Science and Technology Agency, Saitama, Japan, Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan

Yuka Yasuda

Affiliations Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan, Core Research for Evolutionary Science and Technology of Japan Science and Technology Agency, Saitama, Japan

Kiyotaka Nemoto

Affiliation Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

Takashi Ohnishi

Affiliations Department of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan, CNS Science Department, Scientific Affairs Division, Janssen Pharmaceutical K.K., Tokyo, Japan

Motoyuki Fukumoto

Affiliations Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan, Core Research for Evolutionary Science and Technology of Japan Science and Technology Agency, Saitama, Japan

Hidenaga Yamamori

Affiliations Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan, Core Research for Evolutionary Science and Technology of Japan Science and Technology Agency, Saitama, Japan, Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan

Satomi Umeda-Yano

Affiliation Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan

Takeya Okada

Affiliations Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan, Core Research for Evolutionary Science and Technology of Japan Science and Technology Agency, Saitama, Japan

Masao Iwase

Affiliation Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan

Hiroaki Kazui

Affiliation Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan

Masatoshi Takeda

Affiliations Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan, Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka, Japan

Competing Interests

Yes, the authors have the following competing interest. This study received funding from the following commercial companies: Janssen Pharmaceutical K.K., Dainippon Sumitomo Pharma Co., Ltd., All Nippon Airways Co., Ltd., Tsumura & Co., Eisai Co., Ltd., Zeria Pharmaceutical Co., Ltd., Yoshitomiyakuhin Corporation, Pfizer Japan Inc., Astellas Pharma Inc., H2O Retailing Corporation, and GlaxoSmithKline. Takashi Ohnishi is employed by Janssen Pharmaceutical K.K. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: KO RH. Performed the experiments: HY SU TOakada KN TOhnishi. Analyzed the data: KO RH KN TOhnishi HY SU TOakada. Contributed reagents/materials/analysis tools: YY MF MI HK MT. Wrote the paper: KO RH YY MF MI HK MT.