About the Authors

Yoshiki Kobayashi

Affiliation Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom

Nicolas Mercado

Affiliation Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom

Peter J. Barnes

Affiliation Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom

Kazuhiro Ito

k.ito@imperial.ac.uk

Affiliation Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom

Competing Interests

Peter J. Barnes and Kazuhiro Ito received project grants from AstraZeneca and AsthmaUK, and Peter J. Barnes received non-restricted scientific funding from GlaxoSmithKline. K. Ito is an employee of RespiVert Ltd. Other authors have declared that no competing interests exist. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YK PJB KI. Performed the experiments: YK NM. Analyzed the data: YK KI. Contributed reagents/materials/analysis tools: YK KI. Wrote the paper: YK PJB KI. Obtained ethics approval: PJB KI.