Use of Low-Coverage, Large-Insert, Short-Read Data for Rapid and Accurate Generation of Enhanced-Quality Draft Pseudomonas Genome Sequences

Heath E. O'Brien; Yunchen Gong; Pauline Fung; Pauline W. Wang; David S. Guttman

doi:10.1371/journal.pone.0027199

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Open Access

Peer-reviewed

Research Article

Use of Low-Coverage, Large-Insert, Short-Read Data for Rapid and Accurate Generation of Enhanced-Quality Draft Pseudomonas Genome Sequences

Heath E. O'Brien ,

* E-mail: heath.obrien@utoronto.ca

Affiliation Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
⨯
Yunchen Gong,

Affiliation Center for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada
⨯
Pauline Fung,

Affiliation Center for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada
⨯
Pauline W. Wang,

Affiliations Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada, Center for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada
⨯
David S. Guttman

Affiliations Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada, Center for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada
⨯

Use of Low-Coverage, Large-Insert, Short-Read Data for Rapid and Accurate Generation of Enhanced-Quality Draft Pseudomonas Genome Sequences

Heath E. O'Brien,
Yunchen Gong,
Pauline Fung,
Pauline W. Wang,
David S. Guttman

Published: November 2, 2011
https://doi.org/10.1371/journal.pone.0027199

About the Authors

Heath E. O'Brien

* E-mail: heath.obrien@utoronto.ca

Affiliation Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada

Yunchen Gong

Affiliation Center for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada

Pauline Fung

Affiliation Center for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada

Pauline W. Wang

Affiliations Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada, Center for the Analysis of Genome Evolution & Function, University of Toronto, Toronto, Ontario, Canada

David S. Guttman

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HEOB DSG. Performed the experiments: PF PWW. Analyzed the data: HEOB YG. Contributed reagents/materials/analysis tools: DSG. Wrote the paper: HEOB DSG.

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Genomics
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Gene prediction
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Bacterial genomics
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Genome sequencing
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Pseudomonas syringae
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Sequence alignment
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Comparative genomics
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Genome annotation
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