About the Authors

Ting Gong

ting.gong@novartis.com

Affiliation Biomarker Development, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

Nicole Hartmann

Affiliation Biomarker Development, Novartis Institutes for BioMedical Research, Basel, Switzerland

Isaac S. Kohane

Affiliation Harvard Medical School, Children's Hospital Medical Center, Boston, Massachusetts, United States of America

Volker Brinkmann

Affiliation Department of Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Basel, Switzerland

Frank Staedtler

Affiliation Biomarker Development, Novartis Institutes for BioMedical Research, Basel, Switzerland

Martin Letzkus

Affiliation Biomarker Development, Novartis Institutes for BioMedical Research, Basel, Switzerland

Sandrine Bongiovanni

Affiliation Biomarker Development, Novartis Institutes for BioMedical Research, Basel, Switzerland

Joseph D. Szustakowski

Affiliation Biomarker Development, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

Competing Interests

TG, NH, VB, FS, ML, SB, JS are employees of Novartis Institutes for BioMedical Research, who funded the study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: TG JS IK VB. Performed the experiments: TG JS. Analyzed the data: TG. Contributed reagents/materials/analysis tools: FS NH ML SB. Wrote the paper: TG NH IK VB FS JS. Generated data: FS NH ML SB.