About the Authors

Jiaqi Huang

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Chris Morehouse

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Katie Streicher

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Brandon W. Higgs

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Jin Gao

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Meggan Czapiga

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Anmarie Boutrin

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Wei Zhu

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Philip Brohawn

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Yong Chang

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Jaye Viner

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Theresa LaVallee

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Laura Richman

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Bahija Jallal

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Yihong Yao

YaoY@MedImmune.com

Affiliation MedImmune, LLC., Gaithersburg, Maryland, United States of America

Competing Interests

All the authors of this manuscript are Medimmune employees and Astrazeneca stock owners. The work presented is entirely funded by MedImmune. MedImmune is developing an anti-IGF monoclonal antibody. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JH CM YC JV TL LR BJ YY. Performed the experiments: JH CM KS BH JG MC AB WZ PB. Analyzed the data: JH CM KS BH WZ YY. Wrote the paper: JH CM KS BH YY JV.