About the Authors

Ayako Kumagai

Affiliations Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan, Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Osaka, Japan

Nanao Horike

Current address: Laboratory of Animal Models for Human Diseases, National Institute of Biomedical Innovation, Osaka, Japan

Affiliations Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan, Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Osaka, Japan

Yudai Satoh

Affiliation Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

Tatsuya Uebi

Affiliation Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Osaka, Japan

Tsutomu Sasaki

Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan

Yumi Itoh

Affiliation Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Osaka, Japan

Yoshiyuki Hirata

Affiliation Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

Kozue Uchio-Yamada

Affiliation Laboratory of Animal Models for Human Diseases, National Institute of Biomedical Innovation, Osaka, Japan

Kazuo Kitagawa

Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan

Shinichi Uesato

Affiliation Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

Hidehisa Kawahara

Affiliation Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

Hiroshi Takemori

takemori@nibio.go.jp

Affiliation Laboratory of Cell Signaling and Metabolic Disease, National Institute of Biomedical Innovation, Osaka, Japan

Yasuo Nagaoka

Affiliation Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HT. Performed the experiments: AK. Analyzed the data: KK SU HK YN. Contributed reagents/materials/analysis tools: NH YS TU TS YI YH KU. Wrote the paper: HT.