About the Authors

Jamie I. MacPherson

Affiliation Computational and Evolutionary Biology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Ben Sidders

Affiliation Pfizer Global Research and Development, Sandwich, United Kingdom

Stefan Wieland

Affiliation The Scripps Research Institute, La Jolla, California, United States ofAmerica

Jin Zhong

Affiliation The Scripps Research Institute, La Jolla, California, United States ofAmerica

Paul Targett-Adams

Affiliation Pfizer Global Research and Development, Sandwich, United Kingdom

Volker Lohmann

Affiliation Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

Perdita Backes

Affiliation Department of Infectious Diseases, Molecular Virology, University of Heidelberg, Heidelberg, Germany

Oona Delpuech-Adams

Affiliation Pfizer Global Research and Development, Sandwich, United Kingdom

Francis Chisari

Affiliation The Scripps Research Institute, La Jolla, California, United States ofAmerica

Marilyn Lewis

Affiliation Pfizer Global Research and Development, Sandwich, United Kingdom

Tanya Parkinson

Affiliation Pfizer Global Research and Development, Sandwich, United Kingdom

David L. Robertson

david.robertson@manchester.ac.uk

Affiliation Computational and Evolutionary Biology, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Competing Interests

BS, PTA, ODA, ML and TP are employees of Pfizer. JIM received a contribution to his PhD funding from Pfizer. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived the microarray experiments: TP SW FC. Produced the cell lines: JZ. Performed HCVcc, hepatoma cell subcloning: SW FC. Managed and validated the microarray work, and performed exploratory analysis: ODA. Produced the set of HRFs: PTA VL PB. Conceived the microarray and meta-analysis: JIM BS ML ODA DLR. Performed the microarray and meta-analysis: JIM. All authors contributed to the manuscript preparation. Wrote the paper: JIM.