About the Authors

Claus Rieker

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland

Kumlesh K. Dev

Affiliation Department of Physiology, School of Medicine, Trinity College Dublin, Dublin, Ireland

Katja Lehnhoff

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland

Samuel Barbieri

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland

Iwona Ksiazek

Current address: Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland

Affiliation Neurobiology Biozentrum, University of Basel, Basel, Switzerland

Sabine Kauffmann

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland

Simone Danner

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland

Heinrich Schell

Affiliation Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany

Cindy Boden

Affiliation Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany

Markus A. Ruegg

Affiliation Neurobiology Biozentrum, University of Basel, Basel, Switzerland

Philipp J. Kahle

Affiliation Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Diseases, University of Tübingen, Tübingen, Germany

Herman van der Putten

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland

Derya R. Shimshek

derya.shimshek@novartis.com

Affiliation Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland

Competing Interests

Claus Rieker, Katja Lehnhoff, Samuel Barbieri, Sabine Kauffmann, Simone Danner Herman van der Putten and Derya Shimshek are employees of Novartis Pharma AG. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: DRS IK MAR PJK HvdP. Performed the experiments: KL SB IK SK SD HS CB DRS. Analyzed the data: IK MAR PJK DRS. Contributed reagents/materials/analysis tools: CR. Wrote the paper: CR KKD PJK HvdP DRS.