About the Authors

Masakiyo Sakaguchi

Affiliation Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan

Hitoshi Murata

Affiliation Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan

Ken-ichi Yamamoto

Affiliation Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan

Tomoyuki Ono

Affiliation Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan

Yoshihiko Sakaguchi

Affiliation Interdisciplinary Research Organization, University of Miyazaki, Kiyotakecho, Miyazaki, Japan

Akira Motoyama

Affiliation Shiseido Research Center, Kanazawa-ku, Yokohama, Japan

Toshihiko Hibino

Affiliation Shiseido Research Center, Kanazawa-ku, Yokohama, Japan

Ken Kataoka

Affiliation Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan

Nam-ho Huh

namu@md.okayama-u.ac.jp

Affiliation Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan

Competing Interests

Akira Motoyama and Toshihiko Hibino are employees of the Shiseido Research Center. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MS HM KK N-hH. Performed the experiments: MS HM K-iY TO YS AM TH KK. Analyzed the data: MS HM KK N-hH. Wrote the paper: MS N-hH. Helped in the interpretation of data and suggested experiments: MS HM KK N-hH.