About the Authors

Wanting Chen

Affiliation Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, United Kingdom

Caroline Hayward

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

Alan F. Wright

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

Andrew A. Hicks

Affiliation Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany

Veronique Vitart

Affiliation MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

Sara Knott

Affiliation Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, Edinburgh, United Kingdom

Sarah H. Wild

Affiliation Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom

Peter P. Pramstaller

Affiliations Institute of Genetic Medicine, European Academy Bozen/Bolzano (EURAC), Bolzano/Bozen, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany, Department of Neurology, General Central Hospital, Bolzano, Italy, Department of Neurology, University of Lübeck, Lübeck, Germany

James F. Wilson

Affiliation Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom

Igor Rudan

Affiliations Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, United Kingdom, Croatian Centre for Global Health, University of Split Medical School, Split, Croatia

David J. Porteous

david.porteous@ed.ac.uk

Affiliation Medical Genetics Section, Centre for Molecular Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WC DJP. Performed the experiments: WC AAH AFW. Analyzed the data: WC. Contributed reagents/materials/analysis tools: VV CH AAH SHW JFW IR PPP SK. Wrote the paper: WC. Discussion and advice: VV CH SK IR JW DJP.