About the Authors

Sachin Yende

yendes@upmc.edu

Affiliations The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Gina D'Angelo

Affiliation Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Florian Mayr

Affiliations The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

John A. Kellum

Affiliations The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Lisa Weissfeld

Affiliations Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Division of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

A. Murat Kaynar

Affiliations The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Tammy Young

Affiliations The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Kaikobad Irani

Affiliation Division of Cardiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Derek C. Angus

Affiliations The Clinical Research, Investigation, and Systems Modeling of Acute Illness Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

for the GenIMS Investigators

Competing Interests

GenIMS received support from GlaxoSmithKline for enrollment and clinical data collection, and Diagnostic Products Corporation for the cytokine assays. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SY DCA JAK. Analyzed the data: GD LW SY DCA FM. Wrote the paper: SY DCA. Critical revisions of the manuscript: JAK FM AMK TY KI.