About the Authors

Ray Yu-Ruei Wang

Affiliations Graduate Program in Biomolecular Structure and Design, University of Washington, Seattle, Washington, United States of America, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Yan Han

Affiliations Graduate Program in Biomolecular Structure and Design, University of Washington, Seattle, Washington, United States of America, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Kristina Krassovsky

Affiliations Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America

William Sheffler

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Michael Tyka

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

David Baker

dabaker@u.washington.edu

Affiliations Graduate Program in Biomolecular Structure and Design, University of Washington, Seattle, Washington, United States of America, Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DB. Performed the experiments: RYW YH KK Analyzed the data: RYW YH KK WS MT DB. Wrote the paper: RYW DB. Designed the software used in modeling: WS RYW YH KK MT.