About the Authors

Fuqu Yu

Contributed equally to this work with: Fuqu Yu, Ibrahim Al-Shyoukh

Address Current address: Johnson & Johnson Pharmaceutical Research & Development LLC, San Diego, California, United States of America,

Affiliation Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

Ibrahim Al-Shyoukh

Contributed equally to this work with: Fuqu Yu, Ibrahim Al-Shyoukh

Affiliations Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America, Mechanical and Aerospace Engineering Department, University of California Los Angeles, Los Angeles, California, United States of America

Jiaying Feng

Affiliation Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

Xudong Li

Affiliation Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

Chia Wei Liao

Affiliation Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

Chih-Ming Ho

Affiliation Mechanical and Aerospace Engineering Department, University of California Los Angeles, Los Angeles, California, United States of America

Jeff S. Shamma

Affiliation School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States of America

Ren Sun

rsun@mednet.ucla.edu

Affiliation Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FY IAS CMH JSS RS. Performed the experiments: FY JF XL CWL. Analyzed the data: IAS FY RS. Contributed reagents/materials/analysis tools: FY IAS JF XL RS. Wrote the paper: IAS FY RS. Introduced the idea to optimize drug combinations using a mathematical feedback algorithm: CHM.