About the Authors

Satoshi Sugita

Affiliation Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Yasutomi Kamei

kamei.mmm@mri.tmd.ac.jp

Affiliation Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Fumiko Akaike

Affiliations Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan, Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan

Takayoshi Suganami

Affiliation Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Sayaka Kanai

Affiliation Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Maki Hattori

Affiliations Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan, Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan

Yasuko Manabe

Affiliation Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan

Nobuharu Fujii

Affiliation Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan

Takako Takai-Igarashi

Affiliation Department of Bioinformatics, Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan

Miki Tadaishi

Affiliations Nutritional Science Program, National Institute of Health and Nutrition, Tokyo, Japan, Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan

Jun-Ichiro Oka

Affiliation Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan

Hiroyuki Aburatani

Affiliation Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan

Tetsuya Yamada

Affiliation Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Miyagi, Japan

Hideki Katagiri

Affiliation Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Miyagi, Japan

Saori Kakehi

Affiliation Department of Medicine, Metabolism and Endocrinology, School of Medicine, Juntendo University, Tokyo, Japan

Yoshifumi Tamura

Affiliations Department of Medicine, Metabolism and Endocrinology, School of Medicine, Juntendo University, Tokyo, Japan, Sportology Center, Juntendo University, Tokyo, Japan

Hideo Kubo

Affiliation Daiichi-Sankyo Co., Ltd., Tokyo, Japan

Kenichi Nishida

Affiliation Daiichi-Sankyo Co., Ltd., Tokyo, Japan

Shinji Miura

Affiliation Nutritional Science Program, National Institute of Health and Nutrition, Tokyo, Japan

Osamu Ezaki

Affiliation Nutritional Science Program, National Institute of Health and Nutrition, Tokyo, Japan

Yoshihiro Ogawa

Affiliations Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan, Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

Competing Interests

HK and KN are currently employed by the commercial company Daiichi-Sankyo Co., Ltd. HK and KN were non-commercially involved in this study. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. Therefore, HK and KN do not have competing interests to disclose.

Author Contributions

Conceived and designed the experiments: JIO KN SS YK OE YO. Performed the experiments: SS YK FA TS SK (Sayaka Kanai) MH YM NF TTI MT HA TY HK (Hideki Katagiri) SK (Saori Kakehi) YT HK (Hideo Kubo) SM. Analyzed the data: SS YK FA TS SK (Sayaka Kanai) MH YM NF TTI HA TY HK (Hideki Katagiri) SK (Saori Kakehi) YT HK (Hideo Kubo) SM. Contributed reagents/materials/analysis tools: TTI HA JIO KN. Wrote the paper: SS YK OE YO.