Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

Kartick C. Pramanik; Srinivas Reddy Boreddy; Sanjay K. Srivastava

doi:10.1371/journal.pone.0020151

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Open Access

Peer-reviewed

Research Article

Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

Kartick C. Pramanik,

Affiliation Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center, Amarillo, Texas, United States of America
⨯
Srinivas Reddy Boreddy,

Affiliation Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center, Amarillo, Texas, United States of America
⨯
Sanjay K. Srivastava

* E-mail: sanjay.srivastava@ttuhsc.edu

Affiliation Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center, Amarillo, Texas, United States of America
⨯

Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

Kartick C. Pramanik,
Srinivas Reddy Boreddy,
Sanjay K. Srivastava

Published: May 25, 2011
https://doi.org/10.1371/journal.pone.0020151

About the Authors

Kartick C. Pramanik

Affiliation Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center, Amarillo, Texas, United States of America

Srinivas Reddy Boreddy

Affiliation Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center, Amarillo, Texas, United States of America

Sanjay K. Srivastava

* E-mail: sanjay.srivastava@ttuhsc.edu

Affiliation Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University of Health Sciences Center, Amarillo, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KCP SRB SKS. Performed the experiments: KCP SRB SKS. Analyzed the data: KCP SRB SKS. Contributed reagents/materials/analysis tools: KCP SRB SKS. Wrote the paper: KCP SKS.

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Mitochondria
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Catalases
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Cancer treatment
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Apoptosis
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Pancreatic cancer
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Antioxidant therapy
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Antioxidants
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Oxidation
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