About the Authors

Agnes Floel

Contributed equally to this work with: Agnes Floel, Tobias Warnecke

agnes.floeel@charite.de (AF); wolf.schaebitz@evkb.de (W-FS)

Affiliations Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany, Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany, Cluster of Excellence NeuroCure, Charité-Universitätsmedizin Berlin, Berlin, Germany

Tobias Warnecke

Contributed equally to this work with: Agnes Floel, Tobias Warnecke

Affiliation Department of Neurology, University of Münster, Münster, Germany

Thomas Duning

Affiliation Department of Neurology, University of Münster, Münster, Germany

Yvonne Lating

Affiliation Department of Neurology, University of Münster, Münster, Germany

Jan Uhlenbrock

Affiliation Department of Neurology, University of Münster, Münster, Germany

Armin Schneider

Affiliation SYGNIS Bioscience, Heidelberg, Germany

Gerhard Vogt

Affiliation SYGNIS Bioscience, Heidelberg, Germany

Rico Laage

Affiliation SYGNIS Bioscience, Heidelberg, Germany

Winfried Koch

Affiliation HAAPACS GmbH, Schriesheim, Germany

Stefan Knecht

Affiliation Department of Neurology, University of Münster, Münster, Germany

Wolf-Rüdiger Schäbitz

agnes.floeel@charite.de (AF); wolf.schaebitz@evkb.de (W-FS)

Affiliation Department of Neurology, Bethel, Evangelisches Krankenhaus Bielefeld (EVKB), Bielefeld, Germany

Competing Interests

AS, RL, GV are employees of SYGNIS Bioscience GmbH. WK is employee of HAPAACS. This was an investigator-initiated trial, and SYGNIS Bioscience provided study material, but was not involved in trial design, study protocol generation, study conduct, or regulatory issues. AS, RL, GV and WK were involved in generating the statistical analysis plan, and conducted statistical analysis of trial outcome. AS, WRS are inventors on a number of patent applications claiming the use of G-CSF for neurological diseases including stroke. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AF AS SK RL W-RS. Performed the experiments: TW TD YL JU. Analyzed the data: GV WK. Contributed reagents/materials/analysis tools: RL TW. Wrote the paper: AF AS SK W-RS.