About the Authors

Sebastian Winsel

Affiliations Global Drug Discovery, Bayer Healthcare, Berlin, Germany, Institute for Chemistry-Biochemistry, Freie Universität Berlin, Berlin, Germany, Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland

Anette Sommer

Affiliation Global Drug Discovery, Bayer Healthcare, Berlin, Germany

Julia Eschenbrenner

Affiliations Global Drug Discovery, Bayer Healthcare, Berlin, Germany, Institut für Biotechnologie, Technische Universität Berlin, Berlin, Germany

Kevin Mittelstaedt

Affiliations Global Drug Discovery, Bayer Healthcare, Berlin, Germany, Department of Medicine, The University of Melbourne, Melbourne, Australia

Ulrich Klar

Affiliation Global Drug Discovery, Bayer Healthcare, Berlin, Germany

Stefanie Hammer

stefanie.hammer@bayer.com (SH); jens.hoffmann@mdc-berlin.de (JH)

Affiliation Global Drug Discovery, Bayer Healthcare, Berlin, Germany

Jens Hoffmann

stefanie.hammer@bayer.com (SH); jens.hoffmann@mdc-berlin.de (JH)

Affiliations Global Drug Discovery, Bayer Healthcare, Berlin, Germany, Experimental Pharmacology, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany

Competing Interests

The authors have read the journal's policy and have the following conflicts: The company had a role in this study in study design, data collection and analysis, decision to publish and preparation of the manuscript. All the authors are employees or former employees of the Bayer Healthcare. Grant support in detail: S. Winsel, J. Eschenbrenner, K. Mittelstaedt recieved commercial research grants from Bayer Healthcare; A. Sommer, U. Klar, S. Hammer, J. Hoffmann are current or former employes of Bayer Healthcare and hold patents on Bayer Healthcare as well as shares on Bayer. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SW AS JE KM UK SH JH. Performed the experiments: SW. Analyzed the data: SW AS SH. Contributed reagents/materials/analysis tools: SW AS JE KM UK SH JH. Wrote the paper: SW AS SH JH.