About the Authors

Dora Dias-Santagata

Affiliation Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Quynh Lam

Affiliation Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Kathy Vernovsky

Affiliation Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, United States of America

Natalie Vena

Affiliations Department of Medical Oncology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Molecular Oncologic Pathology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America

Jochen K. Lennerz

Affiliation Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Darrell R. Borger

Affiliation Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, United States of America

Tracy T. Batchelor

Affiliations Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Neurology and Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Keith L. Ligon

Affiliations Department of Medical Oncology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Molecular Oncologic Pathology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

A. John Iafrate

Affiliation Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Azra H. Ligon

Affiliations Center for Molecular Oncologic Pathology, Dana–Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

David N. Louis

Affiliation Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Sandro Santagata

ssantagata@partners.org

Affiliations Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

DDS and AJI submitted a patent application for the SNaPshot genotyping methods used in this study. DDS, AJI and DRB have been consultants for Bio-Reference Laboratories, Inc.

Author Contributions

Conceived and designed the experiments: DDS SS. Performed the experiments: DDS QL KV NV AHL SS. Analyzed the data: DDS QL JKL NV AHL DNL SS. Contributed reagents/materials/analysis tools: DDS JKL DRB KLL TTB AJI AHL DNL SS. Wrote the paper: DDS SS.