About the Authors
- Evgeny V. Berdyshev
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Affiliations Department of Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America, Institute for Personalized Respiratory Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America
- Irina Gorshkova
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Affiliations Department of Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America, Institute for Personalized Respiratory Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America
- Peter Usatyuk
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Affiliations Department of Pharmacology, The University of Illinois at Chicago, Chicago, Illinois, United States of America, Institute for Personalized Respiratory Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America
- Satish Kalari
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Affiliation Department of Cancer Biology, Beckman Research Institute, Duarte, California, United States of America
- Yutong Zhao
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Affiliation Department of Medicine, University of Pittsburgh Medical Center, Pittsburg, Pennsylvania, United States of America
- Nigel J. Pyne
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Affiliation Cell Biology Group, University of Strathclyde, Glasgow, United Kingdom
- Susan Pyne
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Affiliation Cell Biology Group, University of Strathclyde, Glasgow, United Kingdom
- Roger A. Sabbadini
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Affiliation Department of Biology, San Diego State University, and Lpath Inc., San Diego, California, United States of America
- Joe G. N. Garcia
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Affiliations Department of Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America, Institute for Personalized Respiratory Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America
- Viswanathan Natarajan
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* E-mail: visnatar@uic.edu
Affiliations Department of Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America, Department of Pharmacology, The University of Illinois at Chicago, Chicago, Illinois, United States of America, Institute for Personalized Respiratory Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America
Competing Interests
Dr. Roger A. Sabbadini is an employee of Lpath Inc., which provided anti-s1P antibody specifically for the experiments carried out as reported in Figure 13. They were consulted prior to submission of this manuscript and had no objection for submission nor any financial claims to this manuscript or studies. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: EVB IG PU VN JGN. Performed the experiments: EVB IG. Analyzed the data: EVB IG PU SK VN. Contributed reagents/materials/analysis tools: YZ NJP SP. Wrote the paper: EVB IR RAS VN.