About the Authors
- Oliver N. F. King
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Contributed equally to this work with: Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai
Affiliation Structural Genomics Consortium, University of Oxford, Headington, United Kingdom
- Xuan Shirley Li
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Contributed equally to this work with: Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai
Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom
- Masaaki Sakurai
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Contributed equally to this work with: Oliver N. F. King, Xuan Shirley Li, Masaaki Sakurai
Current address: Mitsubishi Tanabe Pharma Corporation, Aoba-ku, Yokohama, Japan
Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- Akane Kawamura
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¶These authors also contributed equally to this work.
Affiliation Department of Chemistry and the Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom
- Nathan R. Rose
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¶These authors also contributed equally to this work.
Affiliation Department of Chemistry and the Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom
- Stanley S. Ng
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Affiliation Structural Genomics Consortium, University of Oxford, Headington, United Kingdom
- Amy M. Quinn
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Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- Ganesha Rai
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Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- Bryan T. Mott
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Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- Paul Beswick
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Current address: Almirall S.A., Barcelona, Spain
Affiliation Structural Genomics Consortium, University of Oxford, Headington, United Kingdom
- Robert J. Klose
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Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom
- Udo Oppermann
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Affiliation Structural Genomics Consortium, University of Oxford, Headington, United Kingdom
- Ajit Jadhav
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Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- Tom D. Heightman
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Affiliation Structural Genomics Consortium, University of Oxford, Headington, United Kingdom
- David J. Maloney
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Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
- Christopher J. Schofield
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Affiliation Department of Chemistry and the Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom
- Anton Simeonov
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* E-mail: asimeono@mail.nih.gov
Affiliation National Institutes of Health Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Competing Interests
CJS is a cofounder of ReOx, a company that is interested in the exploitation of the hypoxic response for therapeutic benefit. The authors declare no other competing interests. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: RJK UO TDH DJM CJS AS. Performed the experiments: ONFK XSL MS AK NRR SSN AMQ GR BTM DJM. Analyzed the data: ONFK XSL MS AK NRR SSN AMQ GR BTM TDH DJM AJ CJS AS. Contributed reagents/materials/analysis tools: ONFK XSL AK NRR SSN GR BTM DJM AJ. Wrote the paper: ONFK XSL MS AK NRR SSN AMQ RJK UO TDH DJM AJ CJS AS.