About the Authors

Carlos Riveros

Affiliation Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia

Drew Mellor

Affiliations Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia, School of Computer Science and Software Engineering, The University of Western Australia, Crawley, Australia

Kaushal S. Gandhi

Affiliation Westmead Millennium Institute, University of Sydney, Westmead, Australia

Fiona C. McKay

Affiliation Westmead Millennium Institute, University of Sydney, Westmead, Australia

Mathew B. Cox

Affiliations Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia, Hunter Medical Research Institute, Newcastle, Australia

Regina Berretta

Affiliation Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia

S. Yahya Vaezpour

Affiliations Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia, Department of Computer Engineering, Amirkabir University of Technology, Tehran, Iran

Mario Inostroza-Ponta

Affiliations Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia, Departamento de Ingeniería Informática, Universidad de Santiago de Chile, Santiago, Chile

Simon A. Broadley

Affiliations School of Medicine, Griffith University, Brisbane, Australia, Department of Neurology, Gold Coast Hospital, Southport, Australia

Robert N. Heard

Affiliation Westmead Millennium Institute, University of Sydney, Westmead, Australia

Stephen Vucic

Affiliation Westmead Millennium Institute, University of Sydney, Westmead, Australia

Graeme J. Stewart

Affiliation Westmead Millennium Institute, University of Sydney, Westmead, Australia

David W. Williams

Affiliation John Hunter Hospital, University of Newcastle, Newcastle, Australia

Rodney J. Scott

Affiliation Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia

Jeanette Lechner-Scott

Affiliation Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia

David R. Booth

Affiliation Westmead Millennium Institute, University of Sydney, Westmead, Australia

Pablo Moscato

Pablo.Moscato@newcastle.edu.au

Affiliations Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine, University of Newcastle, and Hunter Medical Research Institute, Newcastle, Australia, Australian Research Council Centre of Excellence in Bioinformatics, St Lucia, Australia

for the ANZgene Multiple Sclerosis Genetics Consortium

Membership of The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) is provided in the Acknowledgments.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GS RJS JLS DB PM. Analyzed the data: CR DM KG RB SYV DB PM. Contributed reagents/materials/analysis tools: RB. Wrote the paper: CR DM SYV SB GS PM. Conducted computational experiments: PM CR DM. Editorial review: PM CR SB. Prepared all figures and supplementary material files: CR DM. Collected samples: FCM MBC SB JLS. Designed analysis software: MIP. Phenotyped patients: SB RNH SV DW.