About the Authors

Laurent-Herve Perez

Contributed equally to this work with: Laurent-Herve Perez, Matt Butler

Affiliation Gastrointestinal Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom

Matt Butler

Contributed equally to this work with: Laurent-Herve Perez, Matt Butler

Affiliation Gastrointestinal Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom

Tammy Creasey

Affiliation Gastrointestinal Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom

JoAnn Dzink-Fox

Affiliation Infectious Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

John Gounarides

Affiliation Analytical Sciences, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Stephanie Petit

Affiliation Gastrointestinal Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom

Anna Ropenga

Affiliation Gastrointestinal Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom

Neil Ryder

Affiliation Infectious Disease Area, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Kathryn Smith

Affiliation Gastrointestinal Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom

Philip Smith

Affiliation Gastrointestinal Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom

Scott J. Parkinson

Scott.Parkinson@novartis.com

Affiliation Gastrointestinal Disease Area, Novartis Institutes for Biomedical Research, Horsham, United Kingdom

Competing Interests

All of the authors are employees of the Novartis Institutes for Biomedical Research (NIBR). Novartis are assignees of a patent submitted for applications related to this work. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JDF NR SJP. Performed the experiments: LHP MB TC JDF JG SP AR KS. Analyzed the data: LHP MB TC JDF JG SP AR NR KS PS SJP. Contributed reagents/materials/analysis tools: LHP MB JDF JG NR PS. Wrote the paper: SJP.