About the Authors

Malcolm A. Leissring

Leissring@mayo.edu

Affiliations Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America, Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America, Center for Neurologic Diseases, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Enrico Malito

Affiliation Ben-May Institute for Cancer Research, University of Chicago, Chicago, Illinois, United States of America

Sabrine Hedouin

Affiliation Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

Lael Reinstatler

Affiliation Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

Tomoko Sahara

Affiliation Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

Samer O. Abdul-Hay

Affiliation Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

Shakeel Choudhry

Affiliation Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

Ghulam M. Maharvi

Affiliation Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

Abdul H. Fauq

Affiliation Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, United States of America

Malwina Huzarska

Affiliation Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America

Philip S. May

Affiliation Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida, United States of America

Sungwoon Choi

Affiliation Laboratory for Drug Discovery in Neurodegeneration, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

Todd P. Logan

Affiliation Center for Neurologic Diseases, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Benjamin E. Turk

Affiliation Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Lewis C. Cantley

Affiliation Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

Marika Manolopoulou

Affiliation Ben-May Institute for Cancer Research, University of Chicago, Chicago, Illinois, United States of America

Wei-Jen Tang

Affiliation Ben-May Institute for Cancer Research, University of Chicago, Chicago, Illinois, United States of America

Ross L. Stein

Affiliation Laboratory for Drug Discovery in Neurodegeneration, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

Gregory D. Cuny

Affiliation Laboratory for Drug Discovery in Neurodegeneration, Brigham & Women's Hospital and Harvard Medical School, Cambridge, Massachusetts, United States of America

Dennis J. Selkoe

Affiliation Center for Neurologic Diseases, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MAL EM BET RLS GDC. Performed the experiments: MAL EM SH LR TS GMM MH PSM SC TPL BET MM. Analyzed the data: MAL EM SH SOAH SC BET WJT GDC DJS. Contributed reagents/materials/analysis tools: SC AHF SC LCC GDC. Wrote the paper: MAL EM SOAH WJT RLS GDC DJS.