About the Authors
- Mathew J. Barber
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Contributed equally to this work with: Mathew J. Barber, Lara M. Mangravite
Affiliation Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
- Lara M. Mangravite
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Contributed equally to this work with: Mathew J. Barber, Lara M. Mangravite
Affiliation Children's Hospital Oakland Research Institute, Oakland, California, United States of America
- Craig L. Hyde
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Affiliation Statistical Application, Pfizer Global Research and Development, Groton, Connecticut, United States of America
- Daniel I. Chasman
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Affiliation Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Joshua D. Smith
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Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
- Catherine A. McCarty
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Affiliation Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America
- Xiaohui Li
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, West Los Angeles, California, United States of America
- Russell A. Wilke
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Affiliation Department of Pharmacology and Toxicology and Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
- Mark J. Rieder
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Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
- Paul T. Williams
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Affiliation Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
- Paul M. Ridker
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Affiliation Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
- Aurobindo Chatterjee
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Affiliation Statistical Application, Pfizer Global Research and Development, Groton, Connecticut, United States of America
- Jerome I. Rotter
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, West Los Angeles, California, United States of America
- Deborah A. Nickerson
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Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
- Matthew Stephens
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Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Department of Statistics, University of Chicago, Chicago, Illinois, United States of America
- Ronald M. Krauss
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* E-mail: rkrauss@chori.org
Affiliation Children's Hospital Oakland Research Institute, Oakland, California, United States of America
Competing Interests
The Treating to New Targets Study (TNT) was funded by Pfizer. CH and AC are full time employees of Pfizer and were involved in analysis and interpretation of the data, as well as revisions to the manuscript. This relationship will not alter the author's ability to adhere to the PLoS data-sharing policy.
Author Contributions
Conceived and designed the experiments: CAM RAW MJR PTW JIR DAN MS RMK. Performed the experiments: MJB CLH DIC JDS. Analyzed the data: MJB LMM CLH DIC XL RAW PTW JIR DAN MS RMK. Contributed reagents/materials/analysis tools: CLH MJR PMR AC MS RMK. Wrote the paper: MJB LMM PTW MS RMK.