About the Authors

Mathew J. Barber

Contributed equally to this work with: Mathew J. Barber, Lara M. Mangravite

Affiliation Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

Lara M. Mangravite

Contributed equally to this work with: Mathew J. Barber, Lara M. Mangravite

Affiliation Children's Hospital Oakland Research Institute, Oakland, California, United States of America

Craig L. Hyde

Affiliation Statistical Application, Pfizer Global Research and Development, Groton, Connecticut, United States of America

Daniel I. Chasman

Affiliation Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Joshua D. Smith

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Catherine A. McCarty

Affiliation Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States of America

Xiaohui Li

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, West Los Angeles, California, United States of America

Russell A. Wilke

Affiliation Department of Pharmacology and Toxicology and Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

Mark J. Rieder

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Paul T. Williams

Affiliation Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Paul M. Ridker

Affiliation Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Aurobindo Chatterjee

Affiliation Statistical Application, Pfizer Global Research and Development, Groton, Connecticut, United States of America

Jerome I. Rotter

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, West Los Angeles, California, United States of America

Deborah A. Nickerson

Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

Matthew Stephens

Affiliations Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Department of Statistics, University of Chicago, Chicago, Illinois, United States of America

Ronald M. Krauss

rkrauss@chori.org

Affiliation Children's Hospital Oakland Research Institute, Oakland, California, United States of America

Competing Interests

The Treating to New Targets Study (TNT) was funded by Pfizer. CH and AC are full time employees of Pfizer and were involved in analysis and interpretation of the data, as well as revisions to the manuscript. This relationship will not alter the author's ability to adhere to the PLoS data-sharing policy.

Author Contributions

Conceived and designed the experiments: CAM RAW MJR PTW JIR DAN MS RMK. Performed the experiments: MJB CLH DIC JDS. Analyzed the data: MJB LMM CLH DIC XL RAW PTW JIR DAN MS RMK. Contributed reagents/materials/analysis tools: CLH MJR PMR AC MS RMK. Wrote the paper: MJB LMM PTW MS RMK.