About the Authors

Matthew R. Henn

mhenn@broadinstitute.org

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Matthew B. Sullivan

Address Current address: Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America

Affiliation Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Nicole Stange-Thomann

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Marcia S. Osburne

Affiliation Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Aaron M. Berlin

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Libusha Kelly

Affiliation Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Chandri Yandava

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Chinnappa Kodira

Address Current address: 454 Life Sciences, Roche, Branford, Connecticut, United States of America

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Qiandong Zeng

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Michael Weiand

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Todd Sparrow

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Sakina Saif

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Georgia Giannoukos

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Sarah K. Young

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Chad Nusbaum

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Bruce W. Birren

Affiliation The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Sallie W. Chisholm

Affiliation Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Competing Interests

Author Chinnappa Kodira currently works at 454 Life Sciences. All of the work reported in this manuscript was completed when he was in residence at the Broad Institute.

Author Contributions

Conceived and designed the experiments: MRH MBS NST MSO AMB LK GG SKY CN SWC. Performed the experiments: NST MW TS GG. Analyzed the data: MRH MBS AMB LK CY CK QZ SS. Contributed reagents/materials/analysis tools: MRH CN BWB SWC. Wrote the paper: MRH MBS MSO SWC.