About the Authors

Wendy L. Imlach

Current address: Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York, United States of America

Affiliations AgResearch, Grasslands Research Centre, Palmerston North, New Zealand, Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand

Sarah C. Finch

Affiliation AgResearch, Ruakura Research Centre, Hamilton, New Zealand

John H. Miller

Affiliation School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand

Andrea L. Meredith

Affiliation Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Julie E. Dalziel


Affiliation AgResearch, Grasslands Research Centre, Palmerston North, New Zealand

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WLI SCF JHM ALM JED. Performed the experiments: WLI. Analyzed the data: WLI JED. Contributed reagents/materials/analysis tools: SCF. Wrote the paper: WLI SCF JHM ALM JED. Isolated the alkaloid compounds and synthesized derivatives: SCF. Supervised the isolated heart experiments: JHM. Supervised the whole animal experiments and generated the Kcnma1−/− mice: ALM.