About the Authors

Paola Sebastiani

Contributed equally to this work with: Paola Sebastiani, Monty Montano

sebas@bu.edu (PS); mmontano@bu.edu (MM)

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Monty Montano

Contributed equally to this work with: Paola Sebastiani, Monty Montano

sebas@bu.edu (PS); mmontano@bu.edu (MM)

Affiliation Department of Medicine Sections of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts, United States of America

Annibale Puca

Affiliation Department of Genetics, IRCCS Multimedica, Milan, Italy

Nadia Solovieff

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Toshio Kojima

Affiliation Computational Systems Biology Research Group, Advanced Science Institute, RIKEN, Yokohama, Kanagawa, Japan

Meng C. Wang

Affiliation Department of Genetics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Efthymia Melista

Affiliation Center for Human Genetics, Boston University School of Medicine, Boston, Massachusetts, United States of America

Micah Meltzer

Affiliation Department of Medicine Sections of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts, United States of America

Sylvia E. J. Fischer

Affiliation Department of Genetics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Stacy Andersen

Affiliation Geriatrics Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Stephen H. Hartley

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America

Amanda Sedgewick

Affiliation Department of Bioengineering, Boston University School of Engineering, Boston, Massachusetts, United States of America

Yasumichi Arai

Affiliation Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

Aviv Bergman

Affiliation Department of Systems & Computational Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Nir Barzilai

Affiliation Institute of Aging Research and Diabetes Research Center, Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America

Dellara F. Terry

Affiliation Geriatrics Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Alberto Riva

Affiliation Department of Molecular Genetics and Microbiology, University of Florida at Gainesville, Florida, United States of America

Chiara Viviani Anselmi

Affiliation Department of Genetics, IRCCS Multimedica, Milan, Italy

Alberto Malovini

Affiliation Department of Genetics, IRCCS Multimedica, Milan, Italy

Aya Kitamoto

Affiliation Computational Systems Biology Research Group, Advanced Science Institute, RIKEN, Yokohama, Kanagawa, Japan

Motoji Sawabe

Affiliation Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

Tomio Arai

Affiliation Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

Yasuyuki Gondo

Affiliation Clinical Thanatology and Geriatric Behavioral Science, Graduate School of Human Sciences, Osaka University, Suita, Osaka, Japan

Martin H. Steinberg

Affiliation Center for Human Genetics, Boston University School of Medicine, Boston, Massachusetts, United States of America

Nobuyoshi Hirose

Affiliation Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

Gil Atzmon

Affiliation Institute of Aging Research and Diabetes Research Center, Departments of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America

Gary Ruvkun

Affiliation Department of Genetics, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Clinton T. Baldwin

These authors also contributed equally to this work.

Affiliation Center for Human Genetics, Boston University School of Medicine, Boston, Massachusetts, United States of America

Thomas T. Perls

These authors also contributed equally to this work.

Affiliation Geriatrics Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PS MM MHS GR CB TP. Performed the experiments: PS MM TK MCW EM MM SEJF YA CVA AK GA CB. Analyzed the data: PS MM NS SHH AS AM TP. Contributed reagents/materials/analysis tools: PS MM AAP TK SLA SHH YA AB NB DT AR MS TA YG MHS NH GA GR CB TP. Wrote the paper: PS MM NS MHS GR CB TP.