About the Authors

Chang-Jiun Wu, Simon Kasif, Martin Steffen
Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America

Tianxi Cai
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

Klarisa Rikova
Cell Signaling Technology, Danvers, Massachusetts, United States of America

David Merberg
Vertex Pharmaceuticals, Cambridge, Massachusetts, United States of America

Simon Kasif
Children's Hospital Informatics Program at the Harvard-MIT Division of Health Sciences and Technology, Boston, Massachusetts, United States of America

Simon Kasif
Center for Advanced Genomic Technology, Boston University, Boston, Massachusetts, United States of America

Martin Steffen
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

Corresponding Author

steffen@bu.edu

Competing Interests

D.M. and K.R. are employees of Vertex Pharmaceuticals and Cell Signaling Technology, respectively. Neither company provided any direct funds for this manuscript or had any role in the analysis, decision to publish, or preparation of the manuscript. These relationships do not alter the authors' adherence to all PLoS ONE policies on sharing data and materials as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SK MS. Performed the experiments: CJW KR. Analyzed the data: CJW TC KR DM SK MS. Wrote the paper: CJW SK MS.