A Reduction in Ribonucleotide Reductase Activity Slows Down the Chromosome Replication Fork but Does Not Change Its Localization

Ingvild Odsbu; Morigen; Kirsten Skarstad

doi:10.1371/journal.pone.0007617

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Open Access

Peer-reviewed

Research Article

A Reduction in Ribonucleotide Reductase Activity Slows Down the Chromosome Replication Fork but Does Not Change Its Localization

Ingvild Odsbu,

Affiliation Department of Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
⨯
Morigen,

Affiliation Department of Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
⨯
Kirsten Skarstad

* E-mail: kirsten.skarstad@rr-research.no

Affiliation Department of Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
⨯

A Reduction in Ribonucleotide Reductase Activity Slows Down the Chromosome Replication Fork but Does Not Change Its Localization

Ingvild Odsbu,
Morigen,
Kirsten Skarstad

Published: October 28, 2009
https://doi.org/10.1371/journal.pone.0007617

About the Authors

Ingvild Odsbu

Affiliation Department of Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway

Morigen

Affiliation Department of Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway

Kirsten Skarstad

* E-mail: kirsten.skarstad@rr-research.no

Affiliation Department of Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IO M KS. Performed the experiments: IO M. Analyzed the data: IO M KS. Contributed reagents/materials/analysis tools: KS. Wrote the paper: IO KS.

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DNA replication
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Nucleotides
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Cell cycle and cell division
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DNA repair
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Flow cytometry
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DNA-binding proteins
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Enzyme structure
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Immunostaining
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