Human Sirt-1: Molecular Modeling and Structure-Function Relationships of an Unordered Protein

Ida Autiero; Susan Costantini; Giovanni Colonna

doi:10.1371/journal.pone.0007350

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Open Access

Peer-reviewed

Research Article

Human Sirt-1: Molecular Modeling and Structure-Function Relationships of an Unordered Protein

Ida Autiero ,

Contributed equally to this work with: Ida Autiero, Susan Costantini

Affiliation CRISCEB (Interdepartmental Research Center for Computational and Biotechnological Sciences) Second University of Naples, Naples, Italy
⨯
Susan Costantini ,

Contributed equally to this work with: Ida Autiero, Susan Costantini

* E-mail: susan.costantini@unina2.it

Affiliations CRISCEB (Interdepartmental Research Center for Computational and Biotechnological Sciences) Second University of Naples, Naples, Italy, CROM (Oncology Research Centre of Mercogliano) “Fiorentino Lo Vuolo”, Mercogliano, Italy, Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy
⨯
Giovanni Colonna

Affiliations CRISCEB (Interdepartmental Research Center for Computational and Biotechnological Sciences) Second University of Naples, Naples, Italy, Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy
⨯

Human Sirt-1: Molecular Modeling and Structure-Function Relationships of an Unordered Protein

Ida Autiero,
Susan Costantini,
Giovanni Colonna

Published: October 8, 2009
https://doi.org/10.1371/journal.pone.0007350

About the Authors

Ida Autiero

Contributed equally to this work with: Ida Autiero, Susan Costantini

Affiliation CRISCEB (Interdepartmental Research Center for Computational and Biotechnological Sciences) Second University of Naples, Naples, Italy

Susan Costantini

Contributed equally to this work with: Ida Autiero, Susan Costantini

* E-mail: susan.costantini@unina2.it

Affiliations CRISCEB (Interdepartmental Research Center for Computational and Biotechnological Sciences) Second University of Naples, Naples, Italy, CROM (Oncology Research Centre of Mercogliano) “Fiorentino Lo Vuolo”, Mercogliano, Italy, Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy

Giovanni Colonna

Affiliations CRISCEB (Interdepartmental Research Center for Computational and Biotechnological Sciences) Second University of Naples, Naples, Italy, Department of Biochemistry and Biophysics, Second University of Naples, Naples, Italy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SC GC. Performed the experiments: IA. Analyzed the data: IA SC GC. Wrote the paper: IA SC GC.

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Molecular dynamics
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Protein structure
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Protein structure prediction
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Globular proteins
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Salt bridges
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Phosphorylation
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Protein interactions
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Simulation and modeling
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