About the Authors

Melody Tsui

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Tiao Xie

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

James D. Orth

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Anne E. Carpenter

Affiliation Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America

Stewart Rudnicki

Affiliation ICCB-Longwood Screening Facility, Harvard Medical School, Boston, Massachusetts, United States of America

Suejong Kim

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Caroline E. Shamu

Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, ICCB-Longwood Screening Facility, Harvard Medical School, Boston, Massachusetts, United States of America

Timothy J. Mitchison

timothy_mitchison@hms.harvard.edu

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MT CES TJM. Performed the experiments: MT JDO SK. Analyzed the data: MT TX SK. Contributed reagents/materials/analysis tools: JDO AEC SR CES. Wrote the paper: MT TX CES TJM.