Single-Molecule LATE-PCR Analysis of Human Mitochondrial Genomic Sequence Variations

Adam Osborne; Arthur H. Reis Jr; Loren Bach; Lawrence J. Wangh

doi:10.1371/journal.pone.0005636

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Open Access

Peer-reviewed

Research Article

Single-Molecule LATE-PCR Analysis of Human Mitochondrial Genomic Sequence Variations

Adam Osborne,

Affiliation Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America
⨯
Arthur H. Reis Jr,

Affiliation Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America
⨯
Loren Bach,

Affiliation Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America
⨯
Lawrence J. Wangh

* E-mail: Wangh@brandeis.edu

Affiliation Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America
⨯

Single-Molecule LATE-PCR Analysis of Human Mitochondrial Genomic Sequence Variations

Adam Osborne,
Arthur H. Reis Jr,
Loren Bach,
Lawrence J. Wangh

Published: May 20, 2009
https://doi.org/10.1371/journal.pone.0005636

About the Authors

Adam Osborne

Affiliation Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America

Arthur H. Reis Jr

Affiliation Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America

Loren Bach

Affiliation Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America

Lawrence J. Wangh

* E-mail: Wangh@brandeis.edu

Affiliation Department of Biology, Brandeis University, Waltham, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AEO AHRJ LB LJW. Performed the experiments: AEO AHRJ LB. Analyzed the data: AEO AHRJ LB. Wrote the paper: AEO AHRJ LJW.

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Mitochondrial DNA
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Signal amplification
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Polymerase chain reaction
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Heteroplasmy
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Mitochondria
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Genomics
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Point mutation
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Contaminants
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