About the Authors

Jamie L. Barger, Tsuyoshi Kayo
LifeGen Technologies, LLC, Madison, Wisconsin, United States of America

James M. Vann, Tomas A. Prolla
Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America

James M. Vann, Tomas A. Prolla
Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America

Edward B. Arias, Gregory D. Cartee
Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America

Jelai Wang
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Timothy A. Hacker, Kurt W. Saupe
Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Ying Wang, Daniel Raederstorff
R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland

Jason D. Morrow
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Jason D. Morrow
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Christiaan Leeuwenburgh
Department of Aging and Geriatrics and College of Medicine, University of Florida, Gainesville, Florida, United States of America

David B. Allison
Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Richard Weindruch
Department of Medicine and Veterans Administration Hospital, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

Corresponding Authors

Competing Interests

T.A. Prolla and R. Weindruch are founders and board directors of LifeGen Technologies, LLC, a company focused on the use of gene expression profiling to understand the mechanisms of action of caloric restriction.

Author Contributions

Conceived and designed the experiments: TP RW. Performed the experiments: TK JV EA TH. Analyzed the data: TP JW RW JB. Contributed reagents/materials/analysis tools: DA JW GC CL KS YW DR JM. Wrote the paper: TP RW JB.