Tuning Curvature and Stability of Monoolein Bilayers by Designer Lipid-Like Peptide Surfactants

Anan Yaghmur; Peter Laggner; Shuguang Zhang; Michael Rappolt

doi:10.1371/journal.pone.0000479

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Open Access

Peer-reviewed

Research Article

Tuning Curvature and Stability of Monoolein Bilayers by Designer Lipid-Like Peptide Surfactants

Anan Yaghmur ,

*To whom correspondence should be addressed. E-mail: anan.yaghmur@oeaw.ac.at

Affiliation Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences, Graz, Austria
⨯
Peter Laggner,

Affiliation Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences, Graz, Austria
⨯
Shuguang Zhang,

Affiliation Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
⨯
Michael Rappolt

Affiliation Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences, Graz, Austria
⨯

Tuning Curvature and Stability of Monoolein Bilayers by Designer Lipid-Like Peptide Surfactants

Anan Yaghmur,
Peter Laggner,
Shuguang Zhang,
Michael Rappolt

Published: May 30, 2007
https://doi.org/10.1371/journal.pone.0000479

About the Authors

Anan Yaghmur

*To whom correspondence should be addressed. E-mail: anan.yaghmur@oeaw.ac.at

Affiliation Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences, Graz, Austria

Peter Laggner

Affiliation Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences, Graz, Austria

Shuguang Zhang

Affiliation Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Michael Rappolt

Affiliation Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences, Graz, Austria

Competing Interests

SZ is one of the inventors of the self-assembling peptides and also a co-founder of 3DM, Inc., an MIT startup that commercializes the peptide surfactants.

Author Contributions

Conceived and designed the experiments: AY PL MR. Performed the experiments: AY. Analyzed the data: SZ AY PL MR. Contributed reagents/materials/analysis tools: SZ. Wrote the paper: AY MR.

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Surfactants
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Lipids
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Macromolecular design
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Lipid structure
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Electrostatics
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Molecular self assembly
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Peptide synthesis
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Phase diagrams
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