NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus

Hanoch Kaphzan; Kenneth J. O'Riordan; Kile P. Mangan; Jonathan M. Levenson; Kobi Rosenblum

doi:10.1371/journal.pone.0000138

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Open Access

Peer-reviewed

Research Article

NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus

Hanoch Kaphzan,

Affiliation Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel
⨯
Kenneth J. O'Riordan,

Affiliation Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Kile P. Mangan,

Affiliation Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Jonathan M. Levenson,

Affiliation Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America
⨯
Kobi Rosenblum

*To whom correspondence should be addressed. E-mail: kobir@psy.haifa.ac.il

Affiliation Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel
⨯

NMDA and Dopamine Converge on the NMDA-Receptor to Induce ERK Activation and Synaptic Depression in Mature Hippocampus

Hanoch Kaphzan,
Kenneth J. O'Riordan,
Kile P. Mangan,
Jonathan M. Levenson,
Kobi Rosenblum

Published: December 27, 2006
https://doi.org/10.1371/journal.pone.0000138

About the Authors

Hanoch Kaphzan

Affiliation Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel

Kenneth J. O'Riordan

Affiliation Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Kile P. Mangan

Affiliation Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Jonathan M. Levenson

Affiliation Department of Pharmacology and the Waisman Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

Kobi Rosenblum

*To whom correspondence should be addressed. E-mail: kobir@psy.haifa.ac.il

Affiliation Center for Brain and Behavior, Department of Neurobiology and Ethology, Haifa University, Haifa, Israel

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KR HK JL. Performed the experiments: HK KO KM. Analyzed the data: KR HK JL. Wrote the paper: KR HK.

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Dopamine
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Hippocampus
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Neurotransmission
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MAPK signaling cascades
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Dopaminergics
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Glycine
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Phosphorylation
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Vitamin C
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