About the Authors

Yaakov A. Levine

Affiliation SetPoint Medical Corporation, Valencia, California, United States of America

Frieda A. Koopman

Affiliation Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands

Michael Faltys

Affiliation SetPoint Medical Corporation, Valencia, California, United States of America

April Caravaca

Affiliation SetPoint Medical Corporation, Valencia, California, United States of America

Alison Bendele

Affiliation Bolder BioPATH, Inc., Boulder, Colorado, United States of America

Ralph Zitnik

Affiliation SetPoint Medical Corporation, Valencia, California, United States of America

Margriet J. Vervoordeldonk

Affiliations Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands, Arthrogen BV, Amsterdam, the Netherlands

Paul Peter Tak

P.P.Tak@amc.uva.nl

Affiliations Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands, GlaxoSmithKline, Stevenage, United Kingdom, University of Cambridge, Cambridge, United Kingdom

Competing Interests

YAL, MF, AC and RZ are employees of SetPoint Medical Corporation. PPT is a consultant to and has received research grants from SetPoint Medical. PPT has become an employee of GlaxoSmithKline (GSK) after completion of the study. GSK has obtained an equity interest in Setpoint Medical Corporation. FAK, AB, and MJV have no competing interests to declare. This does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YAL MF AB RZ PPT. Performed the experiments: YAL FAK AC AB. Analyzed the data: YAL FAK AB RZ MJV PPT. Contributed reagents/materials/analysis tools: YAL FAK AB RZ MJV PPT. Wrote the paper: YAL FAK RZ MJV PPT. Designed and developed the external pulse generator and software environment: MF.