About the Authors

John C. Chambers

Contributed equally to this work with: John C. Chambers, James Abbott, Weihua Zhang, Ernest Turro, James Scott, Sarah Butcher, Paul Elliott, Jaspal S. Kooner

john.chambers@ic.ac.uk (JCC); p.elliott@imperial.ac.uk (PE); j.kooner@imperial.ac.uk (JK)

Affiliations Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom, Imperial College Healthcare NHS Trust, London, United Kingdom, MRC-HPA Centre for Environment and Health, Imperial College London, Norfolk Place, London, United Kingdom, Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom

James Abbott

Contributed equally to this work with: John C. Chambers, James Abbott, Weihua Zhang, Ernest Turro, James Scott, Sarah Butcher, Paul Elliott, Jaspal S. Kooner

Affiliation Centre for Integrative Systems Biology and Bioinformatics, Imperial College London, London, United Kingdom

Weihua Zhang

Contributed equally to this work with: John C. Chambers, James Abbott, Weihua Zhang, Ernest Turro, James Scott, Sarah Butcher, Paul Elliott, Jaspal S. Kooner

Affiliations Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom, Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom

Ernest Turro

Contributed equally to this work with: John C. Chambers, James Abbott, Weihua Zhang, Ernest Turro, James Scott, Sarah Butcher, Paul Elliott, Jaspal S. Kooner

Affiliations Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom, Computational Biology and Statistics, University of Cambridge, Cambridge, United Kingdom

William R. Scott

Affiliation Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom

Sian-Tsung Tan

Affiliations Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom, NHLI, Imperial College London, Hammersmith Hospital, London, United Kingdom

Uzma Afzal

Affiliation Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom

Saima Afaq

Affiliation Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom

Marie Loh

Affiliation Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom

Benjamin Lehne

Affiliation Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom

Paul O'Reilly

Affiliation Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom

Kyle J. Gaulton

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Richard D. Pearson

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Xinzhong Li

Affiliations Institute of Clinical Sciences, Imperial College London, London, United Kingdom, Royal Brompton and Harefield Hospitals NHS Trust, London, United Kingdom

Anita Lavery

Affiliation Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom

Jana Vandrovcova

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom

Mark N. Wass

Affiliation Centre for Integrative Systems Biology and Bioinformatics, Imperial College London, London, United Kingdom

Kathryn Miller

Affiliation Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom

Joban Sehmi

Affiliations Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom, NHLI, Imperial College London, Hammersmith Hospital, London, United Kingdom

Laticia Oozageer

Affiliation Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom

Ishminder K. Kooner

Affiliation Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom

Abtehale Al-Hussaini

Affiliation Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom

Rebecca Mills

Affiliation Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom

Jagvir Grewal

Affiliation Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom

Vasileios Panoulas

Affiliation Imperial College Healthcare NHS Trust, London, United Kingdom

Alexandra M. Lewin

Affiliation Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom

Korrinne Northwood

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom

Gurpreet S. Wander

Affiliation Hero DMC Heart Institute, Dayanand Medical College and Hospital, Ludhiana, India

Frank Geoghegan

Affiliation Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom

Yingrui Li

Affiliation BGI-Shenzhen, Shenzhen, China

Jun Wang

Affiliation BGI-Shenzhen, Shenzhen, China

Timothy J. Aitman

Affiliation MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom

Mark I. McCarthy

Affiliations Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom, Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom

James Scott

Contributed equally to this work with: John C. Chambers, James Abbott, Weihua Zhang, Ernest Turro, James Scott, Sarah Butcher, Paul Elliott, Jaspal S. Kooner

Affiliation NHLI, Imperial College London, Hammersmith Hospital, London, United Kingdom

Sarah Butcher

Contributed equally to this work with: John C. Chambers, James Abbott, Weihua Zhang, Ernest Turro, James Scott, Sarah Butcher, Paul Elliott, Jaspal S. Kooner

Affiliation Centre for Integrative Systems Biology and Bioinformatics, Imperial College London, London, United Kingdom

Paul Elliott

Contributed equally to this work with: John C. Chambers, James Abbott, Weihua Zhang, Ernest Turro, James Scott, Sarah Butcher, Paul Elliott, Jaspal S. Kooner

john.chambers@ic.ac.uk (JCC); p.elliott@imperial.ac.uk (PE); j.kooner@imperial.ac.uk (JK)

Affiliations Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, United Kingdom, Imperial College Healthcare NHS Trust, London, United Kingdom, MRC-HPA Centre for Environment and Health, Imperial College London, Norfolk Place, London, United Kingdom

Jaspal S. Kooner

Contributed equally to this work with: John C. Chambers, James Abbott, Weihua Zhang, Ernest Turro, James Scott, Sarah Butcher, Paul Elliott, Jaspal S. Kooner

john.chambers@ic.ac.uk (JCC); p.elliott@imperial.ac.uk (PE); j.kooner@imperial.ac.uk (JK)

Affiliations Imperial College Healthcare NHS Trust, London, United Kingdom, Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom, NHLI, Imperial College London, Hammersmith Hospital, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JCC JA ET TA MM J. Scott PE JK. Performed the experiments: JCC JA WZ ET KG RP XL KN YL JW TA MM J. Scott SB PE JK. Analyzed the data: JCC JA WZ ET WS ST ML BL PO KG RP XL AL JV MW J. Sehmi KN TA MM J. Scott SB PE JK. Contributed reagents/materials/analysis tools: JCC JA WZ ET WS ST ML BL PO KG RP XL AL JV MW KM J. Sehmi LO IK AA UA RM JG VP AML KN GW FG YL JW TA MM J. Scott SB PE JK SA. Wrote the paper: JCC JA ET TA MM J. Scott PE JK.