7-Ketocholesterol-Induced Inflammation Signals Mostly through the TLR4 Receptor Both In Vitro and In Vivo

Jiahn-Dar Huang; Juan Amaral; Jung Wha Lee; Ignacio R. Rodriguez

doi:10.1371/journal.pone.0100985

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Open Access

Peer-reviewed

Research Article

7-Ketocholesterol-Induced Inflammation Signals Mostly through the TLR4 Receptor Both In Vitro and In Vivo

Jiahn-Dar Huang,

Affiliation Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Juan Amaral,

Affiliation Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jung Wha Lee,

Affiliation Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ignacio R. Rodriguez

* E-mail: rodriguezi@nei.nih.gov

Affiliation Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

7-Ketocholesterol-Induced Inflammation Signals Mostly through the TLR4 Receptor Both In Vitro and In Vivo

Jiahn-Dar Huang,
Juan Amaral,
Jung Wha Lee,
Ignacio R. Rodriguez

Published: July 18, 2014
https://doi.org/10.1371/journal.pone.0100985

About the Authors

Jiahn-Dar Huang

Affiliation Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Juan Amaral

Jung Wha Lee

Ignacio R. Rodriguez

* E-mail: rodriguezi@nei.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JDH IRR. Performed the experiments: JDH JA JWL. Analyzed the data: JDH IRR JA. Contributed reagents/materials/analysis tools: IRR. Contributed to the writing of the manuscript: JDH IRR.

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Inflammation
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Cell death
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Toll-like receptors
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Cytokines
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Small interfering RNA
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Immune receptor signaling
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Hyperexpression techniques
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Inflammasomes
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