About the Authors

Jason E. Ekert

jekert@its.jnj.com

Affiliation Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America

Kjell Johnson

Affiliation Arbor Analytics, LLC, Ann Arbor, Michigan, United States of America

Brandy Strake
Jose Pardinas

Affiliation Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America

Stephen Jarantow

Affiliation Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America

Robert Perkinson

Affiliation Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America

David C. Colter

Affiliation Biologics Research, Biotechnology Center of Excellence, Janssen R&D, LLC, Pharmaceutical Companies of Johnson & Johnson, Spring House, Pennsylvania, United States of America

Competing Interests

This research was supported by Janssen R&D. All authors were employed or contracted by Janssen R&D or affiliated with Arbor Analytics, LLC during this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: JEE KJ BS JP SJ RP DCC. Performed the experiments: JEE BS JP SJ RP. Analyzed the data: JEE KJ BS JP SJ RP DCC. Contributed reagents/materials/analysis tools: JEE BS JP SJ RP. Wrote the paper: JEE KJ JP SJ DCC.