About the Authors

Cecilia L. Speyer

Affiliations Tumor Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Ali H. Hachem

Affiliation University of Michigan, Dearborn, Michigan, United States of America

Ali A. Assi

Affiliation University of Michigan, Dearborn, Michigan, United States of America

Jennifer S. Johnson

Affiliation Van Andel Research Institute, Grand Rapids, Michigan, United States of America

John A. DeVries

Affiliation Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan, United States of America

David H. Gorski

gorskid@med.wayne.edu

Affiliations Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Competing Interests

The authors have the following interests. This study was partly funded by a Grants-4Targets grant from Bayer Healthcare. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: CLS DHG. Performed the experiments: CLS AHH AAA JSJ JAD. Analyzed the data: CLS AHH AAA JSJ JAD DHG. Contributed reagents/materials/analysis tools: DHG. Wrote the paper: CLS DHG.