About the Authors

Keitaro Imaizumi

Current address: Kyokuto Pharmaceutical Industrial Co. Ltd., Nihonbashi Kobunecho, Chuo-ku, Tokyo, Japan

Affiliations Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan, Kobe office, RIKEN Cell Tech Co. Ltd., Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan

Naoki Nishishita

Affiliations Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan, Division of Cell Therapy, Foundation for Biomedical Research and Innovation, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan

Marie Muramatsu

Affiliation Division of Cell Therapy, Foundation for Biomedical Research and Innovation, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan

Takako Yamamoto

Affiliation Division of Cell Therapy, Foundation for Biomedical Research and Innovation, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan

Chiemi Takenaka

Affiliations Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan, Division of Cell Therapy, Foundation for Biomedical Research and Innovation, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan

Shin Kawamata

kawamata@fbri.org (SK); t.akuta@kyokutoseiyaku.co.jp (TA)

Affiliations Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan, Division of Cell Therapy, Foundation for Biomedical Research and Innovation, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan

Kenichiro Kobayashi

Affiliations Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan, Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Okura, Setagaya-ku, Tokyo, Japan

Shin-ichi Nishikawa

Affiliation Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan

Teruo Akuta

kawamata@fbri.org (SK); t.akuta@kyokutoseiyaku.co.jp (TA)

Affiliations Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan, Kobe office, RIKEN Cell Tech Co. Ltd., Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, Japan

Competing Interests

Keitaro Imaizumi (KI) and Teruo Akuta (TA) were employed by a RIKEN spinoff company, RIKEN Cell Tech Co., Ltd. and are now employees of Kyokuto Pharmaceutical Industrial Co., Ltd. Products by Kyokuto Pharmaceutical Industrial were used in this study. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KI SK TA. Performed the experiments: KI NN MM TY CT TA. Analyzed the data: KI NN KK TA. Wrote the paper: KI SK SN TA.