About the Authors

Patricia T. Yam

patricia.yam@gmail.com

¤ Current address: Molecular Biology of Neural Development, Institut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, Canada

Affiliations Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada, Program in Neuroengineering, McGill University, Montreal, Quebec, Canada

Zachary Pincus

Affiliation Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America

Gagan D. Gupta

Affiliation Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

Mikhail Bashkurov

Affiliation Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

Frédéric Charron

Affiliations Program in Neuroengineering, McGill University, Montreal, Quebec, Canada, Molecular Biology of Neural Development, Institut de Recherches Cliniques de Montréal (IRCM), Montreal, Quebec, Canada, Department of Medicine, University of Montreal, Montreal, Quebec, Canada, Department of Anatomy and Cell Biology, Department of Biology, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada

Laurence Pelletier

Affiliations Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

David R. Colman

† Deceased

Affiliations Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada, Program in Neuroengineering, McGill University, Montreal, Quebec, Canada

Competing Interests

The authors declare that they received funding from Rio Tinto Alcan, and that this does not alter their adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PTY DRC. Performed the experiments: PTY. Analyzed the data: PTY ZP GDG. Contributed reagents/materials/analysis tools: ZP GDG MB FC LP. Wrote the manuscript: PTY.