About the Authors

Anna H. Chen

Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America

Avi Robinson-Mosher

Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America

David F. Savage

Affiliation Department of Molecular and Cell Biology, Department of Chemistry and Energy Biosciences Institute, University of California, Berkeley, California, United States of America

Pamela A. Silver

pamela_silver@hms.harvard.edu

Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America

Jessica K. Polka

Affiliations Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America

Competing Interests

PAS serves on the Editorial Board of PLOS Biology.

Author Contributions

Conceived and designed the experiments: AHC DFS PAS JKP. Performed the experiments: AHC JKP. Analyzed the data: AHC ARM JKP. Contributed reagents/materials/analysis tools: AHC ARM DHS. Wrote the manuscript: AHC DHS PAS JKP.